Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells

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• 作者：Sarah E. Carden¹ ; Gregory T. Walker² ; Jared Honeycutt¹ ; Kyler Lugo¹ ; Trung Pham¹ ; Amanda Jacobson¹ ; Donna Bouley³ ; Juliana Idoyaga¹ ; Renee M. Tsolis² ; Denise Monack¹ ; ⁴ ; ^{dmonack@stanford.edu}
• 关键词：nontyphoidal Salmonella ; pathogenesis ; evolution ; niche adaptation ; iNTS ; NTS ; pseudogene ; SrfH ; T3SS effectors ; genome degradation
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：182-194
• 全文大小：3181 K
• 卷排序：21

文摘

ST313 S. Typhimurium isolate D23580 hyperdisseminates to systemic sites in mice ST313 isolate D23580 infects a higher number of CD11b+ migratory DCs in the MLN ST313 isolate D23580 requires CCR7-dependent migration of DCs to hyperdisseminate Pseudogenization of sseI in the ST313 lineage contributes to hyperdissemination