Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neoplasms
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- 作者：Luigi Gugliottaa ; luigi.gugliotta@unibo.it" class="auth_mail" title="E-mail the corresponding author ; Alessandra Iurlob ; Gabriele Gugliottaa ; Alessia Tieghic ; Giorgina Specchiad ; Gianluca Gaidanoe ; Potito R. Scalzullif ; Elisa Rumig ; Alfredo Draganih ; Vincenzo Martinellii ; Cristina Santoroj ; Maria Luigia Randik ; Giuseppe Tagariellol ; Anna Candonim ; Daniele Cattaneob ; Alessandra Riccod ; Raffaele Palmierin ; Marina A. Liberatio ; Maria Langellap ; Angela Ragoq ; Micaela Bergamaschir ; Paola Monaris ; Rossella Miglios ; Umberto Santorot ; Rossella Cacciolau ; Serena Rupoliv ; Lucia Mastrullow ; Pellegrino Mustox ; Maria Gabriella Mazzucconij ; Marco Vignettij ; Agostino Cortelezzib ; Nicola Vianellia ; Bruno Martinoy ; Valerio De Stefanoz ; Francesco PassamontiA ; Alessandro M. VannucchiB ; for the Registro Italiano Trombocitemie RIT1
- 关键词：Thrombocythemia ; Thrombosis ; Platelets ; Leukocytes ; Hematocrit ; JAK2
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：18-25
- 全文大小：1247 K
文摘
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The analysis of prior thrombosis disclosed unbiased pro-thrombotic features in MPN.
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Minor thrombocytosis showed a notable pro-thrombotic effect (hemostatic paradox).
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Erythrocytosis had a pro-thrombotic effect also in MPN other than PV.
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Leukocytosis, JAK2 mutation, and CVRFs confirmed their pro-thrombotic value.