- 作者：Maria Luisa Mateos-Lindemann ; Mar铆a Diez-Aguilar ; Ana Gonz谩lez-Galdamez ; Javier Graus-Morales ; Ana Moreno-Zamora ; Maria Teresa Perez-Gracia
- 关键词：Hepatitis ; E ; Virus de la hepatitis ; E ; Hepatitis aguda ; Hepatitis fulminante
- 刊名：Enfermedades Infecciosas y Microbiolog铆a Cl铆nica
- 出版年：November, 2013
- 年：2013
- 卷：31
- 期：9
- 页码：595-598
- 全文大小：372 K
Objective
To study the clinical and epidemiological profiles of in 43 cases of acute hepatitis, 5 cases of fulminant hepatitis, and one of chronic hepatitis due to hepatitis E virus (HEV), detected over a 7-year period.
Patients
Forty-nine individuals (33 male and 10 female) treated between 2004 and 2011 in the Hospital Ram贸n y Cajal (Comunidad de Madrid, Spain). The diagnosis was made by the detection of IgG and IgM anti-HEV and RNA HEV in serum samples. Acute hepatitis E was defined by the presence of IgM anti-HEV and/or RNA HEV in serum, and chronic hepatitis E if the ARN was detectable more than 6 months. Fulminant hepatitis E was diagnosed if encephalopathy was observed in addition to IgM anti-HEV and/or RNA HEV in serum.
Results
The median age was 46.67 and 49.6 years in acute hepatitis E and fulminant hepatitis E, respectively. The risk factors recorded were travel to endemic areas in 13 patients, 4 were in contact with animals, 4 suffered from hepatic steatosis due to alcohol consumption, 3 consumed uncontrolled foods, and 2 drank water from streams.
Discussion
HEV is the cause of acute self-limited hepatitis, although 36.73% of the studied cases had to be hospitalised. However a small number of patients, 10.2%, had fulminant hepatitis requiring liver transplant. Chronic hepatitis E is very infrequent in immunocompetent individuals. The increase in incidence of hepatitis E is due to the introduction of better diagnostic tests in recent years.