Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a
详细信息 查看全文
- 作者：Basak Icli
- 关键词：MicroRNA ; Diabetes ; Wound healing ; Angiogenesis
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：151-159
- 全文大小：1436 K
文摘
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- <p id="p0005">Expression of miR-26a is induced by high glucose in endothelial cells and post-wounding in the skin of diabetic db/db mice.p>
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- <p id="p0010">Local inhibition of miR-26a promotes angiogenesis and dermal wound healing in db/db mice by increasing endothelial SMAD1.p>
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- <p id="p0015">Local inhibition of miR-26a had no effect on dermal leukocyte accumulation.p>
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- <p id="p0020">MiR-26a may be important in the regulation of the angiogenic response in diabetic wound healing.p>