Neurotrophic factors in Parkinson's disease are regulated by exercise: Evidence-based practice
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- 作者：Paula Grazielle Chaves da Silvaa ; Daniel Desidé ; rio Dominguesa ; Litia Alves de Carvalhoa ; Silvana Allodia ; b ; Clynton Lourenç ; o Correaa ; c ; clyntoncorrea@hucff.ufrj.br" class="auth_mail" title="E-mail the corresponding author ; clyntoncorrea@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; Exercise ; Neuroprotective agents ; Animal model
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：363
- 期：Complete
- 页码：5-15
- 全文大小：838 K
文摘
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A review based on 10 studies on neurotrophic factors (NFs) and exercise was conducted
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NFs act directly or indirectly on neuroprotection.
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BDNF and GDNF directly regulate tyrosine hydroxylase synthesis.
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VEGF and IGF-1 act indirectly, regulating blood supply and synaptic activity.
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Voluntary and forced exercises promote positive influence by NFs upregulation.