Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine
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- 作者：Dominika Pilata ; 1 ; Anna Piotrowskaa ; 1 ; Ewelina Rojewskaa ; Agnieszka Jurgaa ; Joanna Ślusarczykb ; Wioletta Makucha ; Agnieszka Basta-Kaimb ; Barbara Przewlockaa ; Joanna Mikaa ; joamika@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; joasia272@onet.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuropathic pain ; IL-18 ; IL-18BP ; IL-18R ; Opioid treatment
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：114-124
- 全文大小：1876 K
文摘
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During neuropathic pain equilibrium between algesic (IL-18) and analgesic (IL-18BP) factors is disrupted.
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LPS-enhance pro- IL-18 in microglia and anti-nociceptive IL-18BP in astroglia primary cultures
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IL-18BP enhances morphine and buprenorphine analgesia in neuropathy.