Toll-like Receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain research network study
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- 作者：Andrew Schrepfa ; Catherine S. Bradleyb ; c ; Michael O&rsquo ; Donnellb ; Yi Luob ; Steven E. Harted ; Karl Krederb ; c ; Susan Lutgendorfa ; b ; c ; susan-lutgendorf@uiowa.edu" class="auth_mail" title="E-mail the corresponding author ; The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
- 关键词：Inflammation ; Toll-like Receptors ; Functional somatic syndromes ; Pain ; Negative affect ; Interstitial Cystitis/Bladder Pain Syndrome
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：49
- 期：Complete
- 页码：66-74
- 全文大小：576 K
文摘
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We measured inflammatory responses in PBMCs to TLR stimulation in IC/BPS patients.
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Greater responses to TLR-4 stimulation were associated with widespread pain.
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Greater responses to TLR-4 stimulation were associated with comorbid conditions.
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TLR-4 mediated inflammation may be a therapeutic target in unexplained chronic pain.