Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation
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- 作者：Gang Wang1 ; 6 ; 7 ; Luyang Cao1 ; 6 ; Xiaowen Liu1 ; 8 ; Nathan A. Sieracki1 ; 9 ; Anke Di1 ; Xi Wen2 ; Yong Chen3 ; Shalina Taylor1 ; 10 ; Xiaojia Huang1 ; Chinnaswamy Tiruppathi1 ; You-yang Zhao1 ; Yuanlin Song4 ; Xiaopei Gao1 ; Tian Jin2 ; Chunxue Bai4 ; Asrar B. Malik1 ; Jingsong Xu1 ; 5 ; 11 ; jingsong.xu@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：12 September 2016
- 年：2016
- 卷：38
- 期：5
- 页码：453-462
- 全文大小：3149 K
文摘
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TRPM2 sensing of ROS shifts neutrophils from migration to bacterial killing
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ROS sensing by TRPM2 is a central stop mechanism for neutrophil migration
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TRPM2 suppresses neutrophil migration through a channel-independent mechanism
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Cys549 is the ROS-sensing site on TRPM2