- 作者：Mar铆a Guzm谩n-Fulgencio ; M贸nica Garc铆a-脕lvarez ; Juan Berenguer ; M陋 脕ngeles Jim茅nez-Sousa ; Jaime Cos铆n ; Daniel Pineda-Tenor ; Ana Carrero ; Teresa Ald谩miz ; Emilio 脕lvarez ; Juan Carlos L贸pez ; Salvador Resino
- 关键词：Vitamin D ; AIDS ; Chronic hepatitis C ; Liver fibrosis ; Hepatic biopsy ; Antiviral therapy
- 刊名：Journal of Infection
- 出版年：February, 2014
- 年：2014
- 卷：68
- 期：2
- 页码：176-184
- 全文大小：696 K
Summary
Objective
To study the association of plasma 25-hydroxy vitamin D (25(OH)D) levels in HIV/HCV coinfected patients with severity of liver disease and virological response to hepatitis C virus (HCV) therapy with pegylated-interferon-alpha plus ribavirin (pegIFN伪/RBV).Methods
A cross-sectional study in 174 HIV/HCV coinfected patients that underwent a liver biopsy previously to start HCV therapy and a retrospective study of 125 of them. Plasma 25(OH)D levels were quantified by enzyme immunoassay. Liver biopsies were evaluated by METAVIR score. A sustained virological response (SVR) was defined as an undetectable serum HCV viral load (<10聽IU/mL) up through 24 weeks after the end of HCV treatment.
Results
The median of plasma 25(OH)D level was 48聽nmol/L (p25th: 32.5; p75th: 56.1) and 27 (15.5%) had 25(OH)D deficiency (<25聽nmol/L). The percentage of 25(OH)D deficiency was higher in patients with significant fibrosis (F聽鈮ヂ?) (92.6% vs. 57.1%; p聽=聽0.010) and moderate necroinflammatory activity grade (A聽鈮ヂ?) (85.2% vs. 60%; p聽=聽0.043). However, adjusted logistic regression analyses showed that 25(OH)D deficiency was only associated with severity of liver disease [F聽鈮ヂ? (OR聽=聽8.47 (95% of confidence interval (CI)聽=聽1.88; 38.3); p聽=聽0.005) and A聽鈮ヂ? (OR聽=聽3.25 (95%CI聽=聽1.06; 10.1); p聽=聽0.040)]. Moreover, any significant relationship was found between 25(OH)D deficiency and SVR after HCV therapy.
Conclusion
Plasma 25(OH)D deficiency was associated with liver disease severity in HIV/HCV coinfected patients, but it was not associated with HCV treatment failure.