Invasive device-related infections after heart surgery

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• 作者：F. 脕lvarez Lerma ; M. Carrasco ; J.J. Otal ; M. Palomar ; P. Olaechea ; X. Peris ; L. Iglesias ; A. Mart铆nez Pellus ; A. Arenzana ; J.C. Ballesteros ; ENVIN-HELICS Study Group
• 关键词：Heart surgery ; Invasive device-associated infections ; Risk factors ; ENVIN-HELICS registry
• 刊名：Medicina Intensiva (English Edition)
• 出版年：December, 2013
• 年：2013
• 卷：37
• 期：9
• 页码：584-592
• 全文大小：482 K

文摘

Objective

To analyze postoperative infections in critically ill patients undergoing heart surgery.

Setting

Intensive care units (ICUs).

Design

An observational, prospective, multicenter study was carried out.

Patients

Patients in the postoperative period of heart surgery admitted to the ICU and included in the ENVIN-HELICS registry between 2005 and 2011.

Main outcome variables

Mechanical ventilation associated pneumonia (MVP), urinary catheter-related infection (UCI), primary bacteremia (PB), PB related to vascular catheters (PB-VC) and secondary bacteremia.

Results

Of a total of 97,692 patients included in the study, 9089 (9.3%) had undergone heart surgery. In 440 patients (4.8%), one or more infections were recorded. Infection rates were 9.94 episodes of MVP per 1000 days of mechanical ventilation, 3.4 episodes of UCI per 1000 days of urinary catheterization, 3.10 episodes of BP-VC per 1000 days of central venous catheter, and 1.84 episodes of secondary bacteremia per 1000 days of ICU stay. Statistically significant risk factors for infection were ICU stay (odds ratio [OR] 1.18, 95%CI 1.16-1.20), APACHE II upon admission to the ICU (OR 1.05, 95%CI 1.03-1.07), emergency surgery (OR 1.67, 95%CI 1.13-2.47), previous antibiotic treatment (OR 1.38, 95%CI 1.04-1.83), and previous colonization by Pseudomonas aeruginosa (OR 18.25, 95%CI 3.74-89.06) or extended spectrum beta-lactamase producing enterobacteria (OR 16.97, 95%CI 5.4-53.2). The overall ICU mortality rate was 4.1% (32.2% in patients who developed one or more infections and 2.9% in uninfected patients) (p < .001).

Conclusions

Of the patients included in the ENVIN-HELICS registry, 9.3% were postoperative heart surgery patients. The overall mortality was low but increased significantly in patients who developed one or more infection episodes.