Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions
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- 作者：Ouyang Chena ; b ; 1 ; Zhouheng Yea ; 1 ; Zhiyong Caoc ; Anatol Manaenkod ; Ke Ningb ; Xiao Zhaie ; Rongjia Zhanga ; Ting Zhanga ; Xiao Cheng ; Wenwu Liuf ; liuwenwu1980@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Xuejun Suna ; sunxjk@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AW ; left ventricular anterior wall thickness ; CK ; creatine kinase ; CK-MB ; MB isoenzyme of creatine kinase ; cTnI ; cardiac troponin I ; GSH ; glutathione ; GSSG ; glutathione disulfide ; H&E ; hematoxylin and eosin ; HR ; heart rate ; IL-1β ; interleukin-1β ; LAD ; left anterior descending coronary artery ; LDH ; lactate dehydrogenase ; LV ; left ventricular ; LVEF ; left ventricular ejection fraction ; LVFS ; left ventricular fractional shortening ; LVIDd ; left ventricular diastolic inner chamber dimensions ; LVIDs ; l
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：1-11
- 全文大小：14677 K
文摘
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Intraperitoneal injection of methane rich saline may reduce myocardial infarct area and heart enzymes after myocardial infarction in a rat model.
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Intraperitoneal injection of methane rich saline may improve the cardiac function and attenuate myocardial remodeling following myocardial infarction.
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Mathane rich saline may exert cardioprotective effects via its anti-oxidative, anti-inflamamtory and anti-apoptotic activities.