Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db/db mice
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- 作者：Sudhakar Veerankia ; 1 ; s0veer02@louisville.edu" class="auth_mail" title="E-mail the corresponding author ; Srikanth Givvimania ; 1 ; Sourav Kundub ; Naira Metrevelia ; Sathnur Pushpakumara ; Suresh C. Tyagia
- 关键词：Akt ; Protein kinase B ; CHD ; Coronary heart disease ; Cx ; Connexin ; Drp-1 ; Dynamin related protein 1 ; EF ; Ejection fraction ; GAPDH ; Glyceraldehyde 3-phosphate dehydrogenase ; HSP60 ; Heat shock protein 60 ; JC-1 ; Tetraethylbenzimidazolylcarbocyanine iodide ; LVIDd ; Left ventricular internal dimension during diastole ; LVPWd ; Left ventricular posterior wall thickness during diastole ; Mfn-2 ; Mitofusin 2 ; MTP ; Mitochondrial membrane transition pore ; OCR ; Oxygen consumption rate ; PS ; Peak shortening ; PGC-1
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：163-173
- 全文大小：1821 K
文摘
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Exercise prevented loss of gap junctional inter cellular communication in obese-diabetic mice.
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Exercise prevented enhancement in the Drp1/Mfn2 ratio and improved contractile function.
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Exercise ameliorated decline in mitochondrial transmembrane potential and resulted in enhanced ATP production.