The effect of a liver-X-receptor ligand on bleomycin induced pulmonary fibrosis in mice

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• 作者：Ying Shi^a ; ¹ ; Qiongju Chen^b ; ¹ ; Haijun Yan^a ; ¹ ; Wei Gu^a ;
• 关键词：Pulmonary fibrosis ; Liver X receptors ; Bleomycin
• 刊名：International Immunopharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：116-121
• 全文大小：1526 K
• 卷排序：41

文摘

We made animal model of pulmonary fibrosis with bleomycin. We found LXRs agonist T0901317 can attenuate bleomycin induced pulmonary fibrosis. After bleomycin treatment, T0901317 can inhibit expression of cytokines and TGF-β1. T0901317 can also inhibit NF-κB activity and I κBα degradation.