Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates
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- 作者：Pol Sanllehí ; a ; c ; José ; -Luí ; s Abada ; Jordi Bujonsb ; Josefina Casasa ; ; Antonio Delgadoa ; c ; delgado@rubam.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sphingolipids ; Enzyme inhibitor ; Sphingosine lyase ; Synthesis ; Stereocontrolled
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：905-915
- 全文大小：1187 K
文摘
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Inhibitors of the sphingosine-1-phosphate lyase (S1PL) are reported.
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Azido sphingosine-1-phosphates are competitive inhibitors in hS1PL and StS1PL.
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Mimics of the aldimine S1PL transition state are weak inhibitors.