5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
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- 作者：Sean Henrya ; Ria Kidnera ; Mary R. Reisenauera ; Igor V. Magedova ; Robert Kissb ; Vé ; ronique Mathieub ; Florence Lefrancc ; Ramesh Dasarid ; Antonio Evidentee ; Xiaojie Yuf ; Xiuye Maf ; Alexander Pertsemlidisf ; Regina Cencicg ; Jerry Pelletierg ; David A. Cavazosh ; Andrew J. Brennerh ; Alexander V. Aksenovi ; Snezna Rogelja ; Alexander Kornienkod ; a_k76@txstate.edu" class="auth_mail" title="E-mail the corresponding author ; Liliya V. Frolovaa ; lfrolova@nmt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glioblastoma ; Apoptosis resistance ; Multidrug resistance ; Translation inhibition ; Lycorine ; Haemanthamine
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：14 September 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：313-328
- 全文大小：1821 K
文摘
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Compounds based on 5,10b-ethanophenanthridine ring-system were synthesized.
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The 5,10b-ethanophenanthridines exhibited single-digit micromolar activities.
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The 5,10b-ethanophenanthridines were active against drug-resistant cancer cells.
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This investigation resulted in the discovery of new bicyclic ring systems.