Blockade of FLT4 suppresses metastasis of melanoma cells by impaired lymphatic vessels
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- 作者：Ji Yoon Leea ; leejiyoon@sangji.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Seok-Ho Hongb ; Minsang Shinc ; Hye-Ryeon Heob ; In Ho Janga ; jih2094@sangji.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanoma cells ; FLT4 antagonist ; Tumor metastasis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：733-738
- 全文大小：2611 K
文摘
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Tumor metastasis is closely involved with lymphatic vessels.
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Metastatic melanoma cells rapidly migrate into lung via lymphatic vessels.
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FLT4 antagonist, MAZ51 can induce impaired lymphatic endothelial cells without proliferation.
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Melanoma metastasis into lung is inhibited by the suppression of FLT4-expressing lymphatic vessels, when MAZ51 treated.