Characterization of peritoneal leukemia-associated macrophages in Notch1-induced mouse T cell acute lymphoblastic leukemia

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• 作者：Shayan Chen^a ; ^c ; Xiao Yang^a ; Wenli Feng^a ; Feifei Yang^a ; Rong Wang^a ; Chong Chen^a ; Lina Wang^a ; Yongmin Lin^a ; Qian Ren^a ; Guoguang Zheng^a ; ^b ; ^{zhengggtjchn@aliyun.com} ; ^{zhenggg@ihcams.ac.cn}
• 关键词：Peritoneal macrophages ; Leukemia-associated macrophages (LAMs) ; Tumor-associated macrophages (TAMs) ; Notch1-induced t cell acute lymphoblastic leukemia ; Activation phenotype
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：35-41
• 全文大小：1543 K
• 卷排序：81

文摘

Per macrophages and Per LAMs simultaneously expressed high level iNOS and Arg1, which was not commonly observed in macrophages from other origins. LAMs from peritoneal, BM and spleen expressed lower level CSF-1, TGF-β1 and VEGF-A than tumor-associated macrophages (TAMs). Diverse responses in the expression of some phenotype-associated genes to leukemia microenvironments were detected among those LAMs. Per LAMs can be sub-divided into CD206+ and CD206− sub-populations, which expressed both M1- and M2-associated genes.