We demonstrated naive human B cells can be efficiently transduced by recombinant HAdV7.
We observed HAdV7 transduction increased the expression of molecules involved in human B cell cross-presentation.
We found that CEA-specific CD8+ T cells are induced by HAd7CEA modified autologous B cells.
We proved that HAdV7-initiated TLR9 signaling is involved in and necessary for effective B cell cross-presentation.