Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes
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- 作者：Chenjia Xua ; Arlene R. Wymana ; Manal A. Alaamerya ; Shannon A. Arguetaa ; F. Douglas Iveya ; John A. Meyersb ; Adam Lernerb ; Tricia H. Burdoa ; Timothy Connollya ; Charles S. Hoffmana ; Thomas C. Chilesa ; chilest@bc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-2 ; interleukin 2 ; PHA ; phytohaemagglutinin ; PMA ; phorbol-12-myristate-13-acetate ; PDE ; phosphodiesterase ; TNFα ; tumor necrosis factor-α ; TCR ; T-cell antigen receptor ; IFNγ ; interferon-γ ; ELISA ; enzyme-linked immunosorbent assay
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：223-232
- 全文大小：2494 K
文摘
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A potent anti-inflammatory compound, BC12, was identified in a PDE7 inhibitor HTS.
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Inhibition of IL-2 induction occurs at the level of transcription.
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A derivative of BC12 that lacks PDE7 inhibitory activity inhibits IL-2 induction.
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BC12 and BC12-4 inhibit much of the inflammatory response in Jurkat T cells.
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The anti-inflammatory action of these compounds is not via a loss of signaling.