Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis
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- 作者：Marco Cosentinoa ; marco.cosentino@uninsubria.it" class="auth_mail" title="E-mail the corresponding author ; Mauro Zaffaronib ; Massimiliano Legnaroa ; Raffaella Bombellia ; Laura Schembria ; Damiano Baroncinib ; Anna Bianchib ; Raffaella Clericic ; Mario Guidottic ; Paola Banfid ; Giorgio Bonod ; Franca Marinoa
- 关键词：Clinically isolated syndrome ; Multiple sclerosis ; Dopaminergic receptors ; Adrenoceptors ; Peripheral blood mononuclear cells ; CD4 ; + T effector lymphocytes ; CD4 ; + T regulatory lymphocytes
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：298
- 期：Complete
- 页码：82-89
- 全文大小：657 K
文摘
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Subjects with CIS may convert to clinically established MS, however no biomarker may predict the individual risk.
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Lymphocyte dopaminergic receptors (DR)- and adrenoceptors (AR)-operated pathways are dysregulated in MS and may predict the response to IFN-β.
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We now show that lymphocyte expression of several DR and AR mRNAs are upregulated in CIS subjects.
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DR D3, α2A-AR, and DR D5 mRNA after first neurologic event correlate with conversion to MS at 12 months, contributing to predict the risk of MS.