E3 ubiquitin ligase: A potential regulator in fibrosis and systemic sclerosis
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- 作者：Xiao-Lei Huanga ; 1 ; Li Zhangb ; 1 ; Yu Duana ; Yu-Jie Wanga ; Jiu-Hua Zhaoc ; Jing Wanga ; jwang2006@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIP4 ; Itch/atrophin-1 interacting protein 4 ; α-SMA ; α-smooth muscle actin ; BMP ; bone morphogenetic proteins ; Cbl-b ; Casitas B-lineage lymphoma-b ; Co-Smad ; common-partner Smad ; dcSSc ; diffuse cutaneous SSc ; ECM ; extracellular matrix ; EMT ; epithelial-mesenchymal transition ; ER ; endoplasmic reticulum ; ERAD ; ER-associated degradation ; GRAIL ; Gene Related to Anergy in Lymphocytes ; HECT ; homologous to the E6 associated protein carboxy terminus ; HSCs ; hepatic stellate cells ; I-Smads ; inhibitory Smads
- 刊名：Cellular Immunology
- 出版年：2016
- 出版时间：August-September 2016
- 年：2016
- 卷：306-307
- 期：Complete
- 页码：1-8
- 全文大小：691 K
文摘
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E3 ubiquitin ligases participate in the regulation of TGF-β signaling.
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E3 ubiquitin ligases involve in fibrosis through TGF-β signaling.
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E3 ubiquitin ligases regulate fibrosis through other mechanisms.
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The role of E3 ligases played in SSc may lead to novel pharmacologic therapies.