The role of ubiquitin ligases in cardiac disease
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- 作者：Monte S. Willisa ; b ; monte_willis@med.unc.edu" class="auth_mail ; Ariana Bevilacquab ; Thomas Pulinilkunnilc ; Petra Kienesbergerc ; Manasi Tannud ; Cam Pattersone
- 关键词：AChRs ; acetylcholine receptors ; AKAP121 ; A-kinase anchor protein 121 ; c-Cbl ; Casitas b-lineage lymphoma ; Cav3 ; cavelin 3 ; CHIP ; c-terminus of Hsp70-interacting protein ; cIAP ; cellular inhibitor of apoptosis ; cMyBP-C ; cardiac myosin binding protein C ; Drp1 ; dynamin-1-like protein ; E1 ; ubiquitin-activating enzyme ; E2 ; ubiquitin-conjugating enzyme ; E3 ; ubiquitin ligase ; Fbxl22 ; F-box and leucine-rich repeat protein 22 ; Fis1 ; fission 1 ; hERG ; human ether-à ; -go-go-related gene ; MAFBx ; atrogin-1
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：June 2014
- 年：2014
- 卷：71
- 期：Complete
- 页码：43-53
- 全文大小：777 K
文摘
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Sarcomere protein turnover in the heart is maintained by the ubiquitin proteasome system (UPS).
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Dysregulation of protein turnover occurs in cardiac hypertrophy, atrophy, and heart failure.
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Ubiquitin ligases (E3s) interact with specific sarcomere protein substrate(s) to mediate turnover.
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Cardiomyocyte E3s regulate cell signaling that controls cell functions including cell death/apoptosis.
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Cardiomyocyte E3 activities depend on disease context and substrate presence and/or quality.