Infection with human T-lymphotropic virus types-1 and -2 (HTLV-1 and -2): Implications for blood transfusion safety

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• 作者：E.L. Murphy ^{murphy@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：HTLV-1 ; Blood transfusion ; Immunoassay ; Prevention and control
• 刊名：Transfusion Clinique et Biologique
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：23
• 期：1
• 页码：13-19
• 全文大小：597 K

文摘

Many countries currently perform antibody screening for HTLV-1 infection in blood donors, and this intervention is likely cost-effective in preventing HTLV-1 related diseases in high prevalence countries. However, a number of high-income countries with low prevalence of HTLV-1 infection also perform universal HTLV-1 screening and debate has arisen regarding the cost-effectiveness of these strategies. Filter-based leukoreduction is likely to substantially reduce HTLV-1 transmission by removing infected lymphocytes, but actual laboratory data on its efficacy is currently lacking. Similarly, cost-effectiveness research on HTLV-1 prevention strategies is limited by poor data on prevalence, transmission efficacy and the cost of treating HTLV1 diseases.