Exploring the efficacy of immersion analgesics in zebrafish using an integrative approach

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• 作者：Paul G. Schroeder^a ; ^{paul.schroeder@apha.gsi.gov.uk} ; ^{pauleschroeder@aol.com} ; Lynne U. Sneddon^b
• 关键词：Zebrafish ; Analgesia ; Immersion ; Fin clip ; Lidocaine ; Welfare
• 刊名：Applied Animal Behaviour Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：187
• 期：Complete
• 页码：93-102
• 全文大小：1616 K
• 卷排序：187

文摘

This study examined the efficacy of three water soluble analgesic drugs for zebrafish. Post nociceptive behavioural patterns after fin clipping resembled those seen after acetic acid injections. Administration of lidocaine resulted in a significant reduction of pain-related behaviours. These results may pave the way for a first usable analgesic immersion protocol for very small fish in research facilities.