Solajiangxins A-C, three new cytotoxic sesquiterpenoids from Solanum lyratum

详细信息    查看全文

• 作者：Fang Yao ; Qin-Lan Song ; Lei Zhang ; Gui-Sheng Li ; Sheng-Jun Dai
• 关键词：Solanum lyratum ; Solanaceae ; Sesquiterpenoids ; Solajiangxins A&ndash ; C ; Cytotoxic activity
• 刊名：Fitoterapia
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：89
• 期：Complete
• 页码：200-204
• 全文大小：566 K

文摘

One new eudesmane-type (1, named solajiangxin A) and two new eudesmane-related sesquiterpenoids (2-3, named solajiangxins B-C) were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of integrated spectroscopic techniques. In vitro, three new sesquiterpenoids were found to show significant cytotoxicities against three human cancer lines (P-388, HONE-1 and HT-29), and gave ED₅₀ values in the range of 1.9-3.7 ¦Ìg/ml.