Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels
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- 作者：Ryan M. Bradleya ; Phillip M. Marvyna ; Juan J. Aristizabal Henaoa ; Emily B. Mardiana ; Steve Georgeb ; Marc G. Aucoinb ; Ken D. Starka ; Robin E. Duncana ; reduncan@uwaterloo.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AGPAT ; acylglycerophosphate acyltransferase ; LPAAT ; lysophosphatidic acid acyltransferase ; PA ; phosphatidic acid ; LPA ; lysophosphatidic acid ; ALCAT ; acyl-CoA ; lysocardiolipin acyltransferase ; LPEAT ; lysophosphatidylethanolamine acyltransferase ; LPCAT ; lysophosphatidylcholine acyltransferase ; DHA ; docosahexanoic acid ; GFP ; green fluorescent protein ; CL ; cardiolipin ; CDP-DAG ; cytidine diphosphate-diacylglycerol ; TLC ; thin layer chromatography ; HA ; hemagglutinin ; DMEM ; Dulbecco's Modified Eagle's Me
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：1851
- 期：12
- 页码：1566-1576
- 全文大小：1075 K
文摘
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10">Discovery that AGPAT4 is mitochondrial and localizes to the outer mitochondrial membrane.
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15">Determination that AGPAT4 only uses lysophosphatidic acid as an acyl acceptor
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Discovery that Agpat4 gene ablation reduces mouse brain PI, PC, and PE