Lipid profiling of lipoprotein X: Implications for dyslipidemia in cholestasis
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- 作者：Susanne Heimerla ; Alfred Boettchera ; Harald Kaulb ; Gerhard Liebischa ; gerhard.liebisch@ukr.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CE ; cholesteryl ester ; ESI-MS/MS ; electrospray ionization tandem mass spectrometry ; FC ; free cholesterol ; FPLC ; fast performance liquid chromatography ; LCAT ; lecithin ; cholesterol acyltransferase ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; LDL-C ; low density lipoprotein cholesterol ; LPC ; lysophosphatidylcholine ; Lp-X ; lipoprotein X ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; PL ; phospholipid ; SAMe ; S-adenosylmethionine ; SM ; sphingomyelin ; TG ; triglyceride ; U
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1861
- 期：8
- 页码：681-687
- 全文大小：1043 K
文摘
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Lp-X, LDL and HDL were isolated from cholestatic and control samples.
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Lp-X, LDL and HDL were subjected to quantitative lipidomic profiling.
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Lipid species analysis of Lp-X reveals high fractions of monounsaturated species.
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LDL and HDL fractions of cholestatic samples reflect the lipid composition of Lp-X.
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Lipid profiling provides evidence for increased hepatic fatty acid and PL synthesis.