MLII mice closely mimic the craniofacial and dental phenotype of MLII patients.
Increased osteoclastogenesis causes alveolar bone loss in MLII.
Missorting of lysosomal enzymes leads to hypercementosis.
Storage material and disturbed collagen synthesis result in gingival hypertrophy.
Mannose 6-phosphate-dependent lysosomal targeting controls periodontal homeostasis.