Scavenger Receptor class B type I (SR-BI): A versatile receptor with multiple functions and actions

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• 作者：Wen-Jun Shen^a ; ^b ; Jie Hu^a ; Zhigang Hu^a ; ^b ; ¹ ; Fredric B. Kraemer^a ; ^b ; Salman Azhar^a ; ^c ; ^{salman.azhar@va.gov" class="auth_mail}
• 关键词：CD36 ; cluster determinant ; CE ; cholesteryl ester ; CHO ; Chinese hamster ovary cells ; CLA-I ; the human CD36 and LIMPII Analogous-1 ; FSH ; follicle stimulating hormone ; HCV ; Hepatitis C virus ; HDL ; high-density lipoprotein ; LH ; luteinizing hormone ; LIMPII ; lysosomal integral membrane protein II ; NHERF1 ; Na+/H+ exchange regulatory factor 1 ; NHERF2 ; Na+/H+ exchange regulatory factor 2 ; NHERF3 ; Na+/H+ exchange regulatory factor 3 ; PDZ ; PSD-95/Discs-large/ZO-1 ; SR-BI ; scavenger receptor class B type I
• 刊名：Metabolism
• 出版年：July 2014
• 年：2014
• 卷：63
• 期：7
• 页码：875-886
• 全文大小：4554 K

文摘

Scavenger receptor class B type I (SR-BI), is a physiologically relevant HDL receptor that mediates selective uptake of lipoprotein (HDL)-derived cholesteryl ester (CE) in vitro and in vivo. Mammalian SR-BI is a 509-amino acid, ~ 82 kDa glycoprotein that contains N- and C-terminal cytoplasmic domains, two-transmembrane domains, as well as a large extracellular domain containing 5–6 cysteine residues and multiple sites for N-linked glycosylation. The size and structural characteristics of SR-BI, however, vary considerably among lower vertebrates and insects. Recently, significant progress has been made in understanding the molecular mechanisms involved in the posttranscriptional/posttranslational regulation of SR-BI in a tissue specific manner. The purpose of this review is to summarize the current body of knowledge about the events and molecules connected with the posttranscriptional/posttranslational regulation of SR-BI and to update the molecular and functional characteristics of the insect SR-BI orthologs.