Investigation of original multivalent iminosugars as pharmacological chaperones for the treatment of Gaucher disease
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- 作者：Eugé ; nie Laigrea ; b ; Damien Hazelarda ; Josefina Casasb ; Jenny Serra-Vinardellc ; Helen Michelakakisd ; Irene Mavridoud ; Johannes M.F.G. Aertse ; Antonio Delgadob ; f ; delgado@rubam.net" class="auth_mail" title="E-mail the corresponding author ; Philippe Compaina ; philippe.compain@unistra.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pharmacological chaperones ; Lysosomal diseases ; Gaucher disease ; Multivalency ; Click-chemistry ; Iminosugars
- 刊名：Carbohydrate Research
- 出版年：2016
- 出版时间：24 June 2016
- 年：2016
- 卷：429
- 期：Complete
- 页码：98-104
- 全文大小：887 K
文摘
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Synthesis of trivalent and tetravalent iminosugars by way of click-chemistry.
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Peracetylated iminosugars as potential prodrugs to treat Gaucher disease.
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Trivalent iminosugars conjugated with morpholine as lysosome-targeting probes.