A novel derivative of riccardin D induces cell death through lysosomal rupture in vitro and inhibits tumor growth in vivo

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• 作者：Yanyan Wang^a ; Lining Wang^a ; Zhongyi Hu^b ; Yuan Ji^a ; Zhaomin Lin^a ; Huiqing Yuan^b ; Mei Ji^a ; Hongxiang Lou^a ; ^{louhongxiang@sdu.edu.cn}
• 关键词：Bisbibenzyl ; Lysosome ; Cathepsin ; Necrosis ; Apoptosis
• 刊名：Cancer Letters
• 出版年：2013
• 出版时间：28 February, 2013
• 年：2013
• 卷：329
• 期：2
• 页码：207-216
• 全文大小：1744 K

文摘

In the present study, the effect of a novel derivative of riccardin D (RD-N) against cancer cell lines was investigated in vitro and in vivo. We found that RD-N accumulated in the lysosomes associated with lysosomal swelling. As a result, the destabilized lysosomes induced cathepsins to release from the lysosomes into the cytosol and induced cell death which displayed features characteristic to both apoptosis and necrosis. In vivo tumor xenograft model indicated treatment of RD-N significantly reduced size and weight of the tumor compared with vehicles. These findings suggest RD-N could be a promising candidate for treatment of cancer.