Activation of glucocorticoid receptors in Müller glia is protective to retinal neurons and suppresses microglial reactivity
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- 作者：Donika Gallinaa ; Christopher Paul Zelinkaa ; Colleen M. Cebullab ; Andy J. Fischera ; Andrew.Fischer@osumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Retina ; Microglia ; Mü ; ller glia ; Neuronal survival ; Retinal detachment
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：273
- 期：Complete
- 页码：114-125
- 全文大小：2976 K
文摘
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Nuclear glucocorticoid receptor (GCR) is found in the Müller glia in the retina.
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GCR-signaling in Müller glia suppresses the reactivity of microglia/macrophages.
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GCR-signaling protects retinal neurons against different types of damages.
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GCR agonists remain neuroprotective when reactive microglia are ablated.