miR-590 accelerates lung adenocarcinoma migration and invasion through directly suppressing functional target OLFM4

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• 作者：Yanhong Liu^a ; Feng Wang^a ; Peng Xu^b ; ^{xupeng163@hainan.com}
• 关键词：microRNA ; miR-590 ; OLFM4 ; Lung adenocarcinoma ; Metastasis
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：466-474
• 全文大小：2468 K
• 卷排序：86

文摘

MicroRNA-590 (miR-590) shows oncogenic functions in various tumor types, but little is known about biological functions of miR-590 in lung adenocarcinoma. In this study, we observe that miR-590 is not only overexpressed in lung adenocarcinoma tissues and metastatic lymph nodes, but also significantly increased in lung adenocarcinoma cell lines. Moreover, gain-of-function and loss-of-function studies show miR-590 serve as a tumor suppressor regulating lung adenocarcinoma cells migration and invasion. Furthermore, OLFM4 is proved to as a functional target for miR-590 to regulate lung adenocarcinoma cells migration and invasion. In conclusion, miR-590 regulates lung adenocarcinoma metastasis through directly modulating functional target OLFM4.