IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients

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• 作者：Inga Koneczny^a ; Jo A.A. Stevens^a ; Anna De Rosa^b ; Saif Huda^c ; Maartje G. Huijbers^d ; ^h ; Abhishek Saxena^a ; Michelangelo Maestri^b ; Konstantinos Lazaridis^e ; ^f ; Paraskevi Zisimopoulou^e ; ^f ; Socrates Tzartos^e ; ^f ; Jan Verschuuren^d ; Silvè ; re M. van der Maarel^h ; Philip van Damme^f ; ^g ; Marc H. De Baets^a ; Peter C. Molenaar^a ; Angela Vincent^c ; Roberta Ricciardi^b ; Pilar Martinez-Martinez^a ; ¹ ; ^{p.martinez@maastrichtuniversity.nl} ; Mario Losen^a ; ¹ ; ^{m.losen@maastrichtuniversity.nl}
• 关键词：Fab-arm exchange ; IgG4 ; MuSK ; Myasthenia gravis ; Autoimmunity
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：Complete
• 页码：104-115
• 全文大小：1631 K
• 卷排序：77

文摘

MuSK autoantibodies can be induced to exchange Fab-arms in vitro. Fab-arm exchange is exclusive for the IgG4 subclass. Most MuSK autoantibodies are bispecific in vivo. Fab-arm exchange with normal IgG4 does not reduce pathogenicity in vitro. Monovalent MuSK antibodies are sufficient to cause disease.