ACKR2: Nature’s Decoy Receptor Lures Unsuspecting Chemokines in Psoriasis

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• 作者：Tomotaka Mabuchi¹ ; Samuel T. Hwang² ; ^{sthwang@ucdavis.edu}
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：1
• 页码：7-11
• 全文大小：670 K
• 卷排序：137

文摘

While we know much about the processes mediated by the Th17 inflammatory pathway that is crucial in psoriasis, we actually know little about the processes by which most psoriatic patients maintain what grossly looks like non-inflamed, normal skin in the face of massive inflammatory changes in nearby affected skin. Other molecular regulators that defend the skin from global inflammation are likely to be involved, including molecules such as ACKR2, an atypical chemokine receptor whose role in psoriasiform dermatitis is explored by Shams et al.