- 作者：Dale C. Hesdorffer ; Shlomo Shinnar ; Darrell V. Lewis ; Douglas R. Nordli Jr. ; John M. Pellock ; Solomon L. Mosh¨¦ ; Ruth C. Shinnar ; Claire Litherl ; Emilia Bagiella ; L. Matthew Frank ; Jacqueline A. Bello ; Stephen Chan ; David Masur ; James MacFall ; Shumei Sun ; Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) Study Team
- 关键词：Columbia Study ; Columbia University Febrile Seizure Study ; FEBSTAT ; Consequences of Prolonged Febrile Seizures in Childhood ; FSE ; Febrile status epilepticus ; FS ; Febrile seizure ; MRI ; Magnetic resonance imaging
- 刊名：The Journal of Pediatrics
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：163
- 期：4
- 页码：1147-1151.e1
- 全文大小：133 K
Objective
To identify risk factors for developing a first febrile status epilepticus (FSE) among children with a first febrile seizure (FS).Study design
Cases were children with a first FS that was FSE drawn from the Consequences of Prolonged Febrile Seizures in Childhood and Columbia cohorts. Controls were children with a first simple FS and separately, children with a first complex FS that was not FSE. Identical questionnaires were administered to family members of the 3 cohorts. Magnetic resonance imaging protocol and readings were consistent across cohorts, and seizure phenomenology was assessed by the same physicians. Risk factors were analyzed using logistic regression.
Results
Compared with children with simple FS, FSE was associated with younger age, lower temperature, longer duration (1-24 hours) of recognized temperature before FS, female sex, structural temporal lobe abnormalities, and first-degree family history of FS. Compared with children with other complex FS, FSE was associated with low temperature and longer duration (1-24 hours) of temperature recognition before FS. Risk factors for complex FS that was not FSE were similar in magnitude to those for FSE but only younger age was significant.
Conclusions
Among children with a first FS, FSE appears to be due to a combination of lower seizure threshold (younger age and lower temperatures) and impaired regulation of seizure duration. Clinicians evaluating FS should be aware of these factors as many episodes of FSE go unnoticed. Further work is needed to develop strategies to prevent FSE