Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand
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- 作者：Christopher Owen Miles ; Alistair L. Wilkins ; Allan D. Hawkes ; Dwayne J. Jensen ; Andrew I. Selwood ; Veronica Beuzenberg ; A. Lincoln MacKenzie ; Janine M. Cooney and Patrick T. Holland
- 关键词：Dinophysis acuta ; Pectenotoxins ; New Zealand ; NMR ; LC-MS
- 刊名：Toxicon
- 出版年：2006
- 出版时间：August 2006
- 年：2006
- 卷：48
- 期：2
- 页码：152-159
- 全文大小：285 K
文摘
Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141–150]. PTX-13 underwent slow deuteration at the 13β-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact.