Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
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- 作者：Hansen Lui1 ; 18 ; Jiasheng Zhang1 ; Stefanie R. Makinson2 ; Michelle K. Cahill1 ; Kevin W. Kelley3 ; Hsin-Yi Huang1 ; 19 ; Yulei Shang1 ; Michael C. Oldham4 ; Lauren Herl Martens5 ; Fuying Gao6 ; Giovanni Coppola6 ; Steven A. Sloan7 ; Christine L. Hsieh8 ; Charles C. Kim9 ; 20 ; Eileen H. Bigio10 ; Sandra Weintraub10 ; Marek-Marsel Mesulam10 ; Rosa Rademakers11 ; Ian R. Mackenzie12 ; William W. Seeley13 ; Anna Karydas13 ; Bruce L. Miller13 ; Barbara Borroni14 ; Roberta Ghidoni15 ; Robert V. Farese Jr.16 ; Jeanne T. Paz2 ; Ben A. Barres7 ; Eric J. Huang1 ; 17 ; eric.huang2@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：165
- 期：4
- 页码：921-935
- 全文大小：7479 K
文摘
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Progranulin regulates lysosomal function and complements production in microglia
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Grn−/− microglia preferentially eliminates inhibitory synapse in ventral thalamus
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Grn−/− mice exhibit hyperexcitability in ventral thalamus and OCD-like behaviors
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Loss of C1qa mitigates neurodegeneration and improves survival in Grn−/− mice