Effect of extremes of body weight on drug level in patient treated with standard dose of rivaroxaban for venous thromboembolism; real life experience
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- 作者：DRJ Arachchillage ; d.arachchillage@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author ; R Reynolds ; T Devey ; R Maclean ; S Kitchen ; JJ van Veen
- 关键词：Rivaroxaban ; Venous thromboembolism ; Treatment outcome ; Safety ; Extremes of body weight
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：32-35
- 全文大小：323 K
文摘
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Patients with extremes of body weight (EBW) are underrepresented in clinical trials.
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Effect of EBW on the drug level with standard dose of rivaroxaban was assessed.
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Rivaroxaban levels were significantly higher in patients of weight < 50 kg than others.
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Bleeding & recurrent VTE rates were not associated with drug levels or body weight.