Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension
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- 作者：Neil MacRitchiea ; Giora Volpertb ; Mohammed Al Washiha ; David G. Watsona ; Anthony H. Futermanb ; Simon Kennedyc ; Susan Pynea ; Nigel J. Pynea ; n.j.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sphingosine kinase ; Sphingosine 1-phosphate ; Hypoxia ; Pulmonary arterial hypertension ; Hypertrophy ; Vascular remodelling
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：946-955
- 全文大小：1808 K
文摘
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PF-543, a sphingosine kinase 1 inhibitor reduces cardiac hypertrophy in a mouse pulmonary arterial hypertension (PAH) model
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This results in reduced cardiomyocyte apoptosis
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PF-543 reduces PARP processing and p53 expression and increases Nrf-2 expression in the right ventricle of mice with PAH