Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

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• 作者：Simranpreet Kaur^a ; ^{simranpreet.Kaur@mater.uq.edu.au} ; Liza Jane Raggatt^a ; ^{liza-jane.raggatt@mater.uq.edu.au} ; Lena Batoon^a ; ^{lena.batoon@mater.uq.edu.au} ; David Arthur Hume^b ; ^{david.hume@roslin.ed.ac.uk} ; Jean-Pierre Levesque^a ; ^{jp.levesque@mater.uq.edu.au} ; Allison Robyn Pettit^a ; ^{allison.pettit@mater.uq.edu.au}
• 关键词：Macrophages ; Stem cell niches ; Haematopoiesis ; Bone and bone marrow
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：12-21
• 全文大小：2344 K
• 卷排序：61

文摘

Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected tissues. Three subsets of bone–bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.