Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages
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- 作者：HuaDong Zhenga ; b ; zhd239@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; DaJiang Cuia ; XiaoJuan Quana ; WeiLin Yanga ; YingNa Lia ; Lin Zhanga ; EnQi Liub ; liuenqi@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lp-PLA2 ; ox-LDL ; Macrophage ; Oxidative stress ; Cell apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：1017-1023
- 全文大小：1139 K
文摘
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ox-LDL induced cell apoptosis and Lp-PLA2 expression in THP-1 cells.
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Lp-PLA2 silencing reduced the formation of foam cells from THP1-derived macrophages.
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Lp-PLA2 silencing reduced ox-LDL-induced oxidative stress and macrophage apoptosis.
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Lp-PLA2 silencing reduced ox-LDL-induced cell apoptosis via Akt/mTOR pathway.