Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL

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• 作者：Juan Toledo^c ; Montserrat Esteve^a ; ^b ; Mar Grasa^a ; ^b ; Angelo Ledda^a ; ^b ; Horacio Garda^c ; José ; Gulfo^a ; ^b ; Ivo Dí ; az Ludovico^c ; Nahuel Ramella^c ; Marina Gonzalez^c ; ^{marinacego@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{marinacego@med.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Low density lipoprotein ; Peroxidative damage ; Cell viability ; Macrophages
• 刊名：Data in Brief
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：8
• 期：Complete
• 页码：251-257
• 全文大小：648 K

文摘

This article supports experimental evidence on the time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded cells. The cells employed were human monocytes THP1 line transformed into macrophages by treatment with phorbol esters. Macrophages were treated at different times with oxidized low density lipoprotein (Ox-LDL) and then gene expression was measured. We also include data about the different types of oxidized lipoprotein obtained (low, media or high oxidation) for differential exposure with Cu ions. These data include characterization to lipid and protein peroxidative damage and also quantification of cell viability by exposure to native and modified LDL. The present article complements data published in “Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1” Ledda et al. (in press) [1].