Non-junction functions of pannexin-1 channels
详细信息 查看全文
- 作者：Brian A. MacVicar ; Roger J. Thompson
- 刊名：Trends in Neurosciences
- 出版年：2010
- 出版时间：February 2010
- 年：2010
- 卷：33
- 期：2
- 页码：93-102
- 全文大小：515 K
文摘
Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic function, astrocytic Ca2+ wave propagation and possibly regulation of vascular tone in the brain. Panx1 activation in various in vitro pathological conditions implicates these channels in ischemic, excitotoxic and ATP-dependent cell death, whereas Panx coupling with purinergic receptors triggers the inflammasome. Novel functions for the pannexin channels are likely to be discovered as current understanding of how they are regulated in physiological and pathological situations improves.