Hyperglycemia-induced inflammation caused down-regulation of 8-oxoG-DNA glycosylase levels in murine macrophages is mediated by oxidative-nitrosative stress-dependent pathways
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- 作者：Premranjan Kumar ; Mitali Madhusmita Swain ; Arttatrana Pal ; arttatrana@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：High glucose ; Macrophages ; Redox signaling ; Apoptosis ; Inflammation
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：82-98
- 全文大小：8910 K
文摘
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Complexity of redox regulation increases in macrophages after high glucose challenges.
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Overproduction of ROS/RNS due to high glucose results in damage to macrophage cell structures.
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High glucose-regulates intracellular signaling pathways in macrophage cells.
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High glucose-mediated alterations in proinflammatory mediators are linked through ROS and RNS in macrophages.