Pathogenesis of thyroid autoimmune disease: the role of cellular mechanisms

详细信息    查看全文

• 作者：Ana Maria Ramos-Leví ; Mó ; nica Marazuela ; ^{monica.marazuela@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Thyroid autoimmunity ; T regulatory cells (Treg) ; T helper ; Th17 ; Graves&rsquo ; disease ; Hashimoto's thyroiditis
• 刊名：Endocrinología y Nutrición (English Edition)
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：63
• 期：8
• 页码：421-429
• 全文大小：915 K

文摘

Hashimoto's thyroiditis (HT) and Graves’ disease (GD) are two very common organ-specific autoimmune diseases which are characterized by circulating antibodies and lymphocyte infiltration. Although humoral and cellular mechanisms have been classically considered separately in the pathogenesis of autoimmune thyroid diseases (AITD), recent research suggests a close reciprocal relationship between these two immune pathways. Several B- and T-cell activation pathways through antigen-presenting cells (APCs) and cytokine production lead to specific differentiation of T helper (Th) and T regulatory (Treg) cells. This review will focus on the cellular mechanisms involved in the pathogenesis of AITD. Specifically, it will provide reasons for discarding the traditional simplistic dichotomous view of the T helper type 1 and 2 pathways (Th1/Th2) and will focus on the role of the recently characterized T cells, Treg and Th17 lymphocytes, as well as B lymphocytes and APCs, especially dendritic cells (DCs).