Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics

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• 作者：Walter Maetzler ; Inga Liepelt ; Matthias Reimold ; Gerald Reischl ; Christoph Solbach ; Clemens Becker ; Claudia Schulte ; Thomas Leyhe ; Stefanie Keller ; Arthur Melms ; Thomas Gasser ; Daniela Berg
• 关键词：Aged ; Amyloid metabolism ; Cerebrospinal fluid ; Diagnostic imaging ; Lewy body disease variant
• 刊名：Neurobiology of Disease
• 出版年：2009
• 出版时间：April 2009
• 年：2009
• 卷：34
• 期：1
• 页码：107-112
• 全文大小：236 K

文摘

About one fourth of Lewy body disease (LBD) patients show cortical β-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [¹¹C]PIB-PET, we tested whether LBD patients with β-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters.

Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [¹¹C]PIB-PET, and were classified as either PIB(+) or PIB(−) according to cortical PIB uptake. PIB(+) and PIB(−) patients were then compared according to demographic, clinical, biochemical and genetic parameters.

None of the PDND, but four PDD and four DLB subjects were PIB(+). In PIB(+) subjects, ApoE4 prevalence was higher, CSF Abeta42 levels were lower and, among demented patients, PIB-binding was associated with a lower MMSE score. Motor symptoms were not associated with PIB binding. Thus, LBD patients with cortical β-amyloid show characteristics usually observed in AD.