Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases
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- 作者：Mehtap Bacioglu1 ; 2 ; 3 ; 10 ; Luis F. Maia1 ; 2 ; 4 ; 10 ; Oliver Preische1 ; 5 ; Juliane Schelle1 ; 2 ; 3 ; Anja Apel1 ; 6 ; Stephan A. Kaeser1 ; 2 ; Manuel Schweighauser1 ; 2 ; 3 ; Timo Eninger1 ; 2 ; 3 ; Marius Lambert1 ; 2 ; Andrea Pilotto1 ; 6 ; Derya R. Shimshek7 ; Ulf Neumann7 ; Philipp J. Kahle1 ; 6 ; Matthias Staufenbiel1 ; 2 ; Manuela Neumann1 ; 8 ; Walter Maetzler1 ; 6 ; Jens Kuhle9 ; 11 ; jens.kuhle@usb.ch" class="auth_mail" title="E-mail the corresponding author ; Mathias Jucker1 ; 2 ; 11 ; mathias.jucker@uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：91
- 期：1
- 页码：56-66
- 全文大小：2379 K
文摘
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Increased NfL in CSF and blood of proteopathic neurodegenerative diseases
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Increased NfL in CSF and blood coincides with onset of proteopathic lesions in brain
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NfL as disease progression and treatment response marker
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Translational value and predictability of current mouse models in clinical settings