Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome

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• 作者：Nesa Marti^a ; ^b ; ^c ; José ; A. Galvá ; n^d ; Amit V. Pandey^a ; ^b ; Mafalda Trippel^d ; Coya Tapia^d ; Michel Mü ; ller^b ; ^e ; Aurel Perren^d ; Christa E. Flü ; ck^a ; ^b ; ^{christa.flueck@dkf.unibe.ch}
• 关键词：Dihydrotestosterone ; Androgen biosynthesis ; Classic and alternative backdoor pathway ; Human ovary ; Testis ; Adrenals ; PCOS ; Androgens
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：116-123
• 全文大小：3706 K
• 卷排序：441

文摘

The human testis is able to produce androgens through the backdoor pathway. Whether the backdoor pathway exists in the human ovary is unknown. The specific genes and proteins of the backdoor pathway are expressed in the ovary. Higher expression of backdoor pathway genes and proteins is observed in PCOS. These data hint a role of the backdoor for androgen synthesis in the ovary.