Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi

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• 作者：Guilherme Curty Lechuga^a ; Jú ; lio Cesar Borges^b ; ^c ; Claudia Magalh&atilde ; es Calvet^d ; Humberto Pinheiro de Araú ; jo^e ; Aline Araujo Zuma^f ; Samara Braga do Nascimento^a ; Maria Cristina Machado Motta^f ; Alice Maria Rolim Bernardino^c ; Mirian Claudia de Souza Pereira^d ; ¹ ; ^{mirian@ioc.fiocruz.br} ; Saulo Cabral Bourguignon^a ; ¹ ; ^{saulocb@globo.com}
• 关键词：Quinoline ; Heme ; Trypanosoma cruzi ; Chemotherapy ; Chagas disease
• 刊名：International Journal for Parasitology: Drugs and Drug Resistance
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：3
• 页码：154-164
• 全文大小：3622 K
• 卷排序：6

文摘

4-arylaminoquinoline-3-carbonitrile derivatives were active against Trypanosoma cruzi. Hemin increased quinoline activity against trypomastigotes and epimastigotes. Combination therapy did not affected mammalian cells. Peroxidation of heme were inhibit by addition of quinoline derivative. Quinoline-heme interactions are proposed as new trypanocidal mechanism.